The Saskatchewan Transportation Company STC offers Saskatchewan's equivalent to Greyhound Bus Lines into the city of Estevan. Greyhound does run through Saskatchewan, however a transfer will be required in Regina or other major city. There is no passenger train service into the city.
The closest international/regional airports are Regina approximately 2 hours away and Minot, North Dakota, USA approximately 2 hours away.
If driving from the USA, closest ports of entry are Noonan, North Dakota and Portal, North Dakota. The North Portal customs office is open 24 hours a day, while the Estevan/Noonan port closes at 9PM.